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Commentary: Better living through chemistry – Jacksonville Journal Courier

On Earth Day, April 22, a hundred thousand people marched all across the world for science. Tens of thousands demonstrated in Los Angeles and London, while 200 people marched 200 miles north of the Arctic circle in Norway. In 600 cities on every continent, citizens and scientists carried signs like Fund science, not walls and Science trumps alternative facts. In Washington, D.C., the biggest crowd protested Donald Trumps proposed budget cuts to scientific research in public health and climate.

Trump is carrying out normal Republican politics. None of the many Republican candidates for president in 2016 thought evolution should be taught in public schools. A majority of Republican voters believe in creationism.

The issue of climate change shows the influence of political ideology on attitudes toward science. A Pew poll found that only 15 percent of conservative Republicans believe the earth is warming mostly due to human activity, 34 percent of moderate Republicans, 63 percent of moderate Democrats and 79 percent of liberal Democrats. A majority of conservative Republicans believes that climate scientists are influenced by a desire to advance their careers and political ideology, not by scientific evidence or public interest.

To put it simply, conservatives dont believe in science or scientists.

Heres how science denial works in real life. Lots of private websites offer their version of science, paid for by private money that they dont disclose, using clever tactics to pretend to search for truth. An example is the Heartland Institute, which has been denying the existence of warming for decades.

On the other side is Understanding Science, a public project of the University of California at Berkeley, funded by the federal National Science Foundation. This step-by-easy-step primer offers a balanced and authentic understanding of how science really works. But those who automatically accuse both government and the nations best universities of politicized scientific fraud would dismiss this site as propaganda. So they wont learn from it how our scientific community does a far better job of policing high standards for honesty and frankness than either politicians or corporations.

And they wont think about who pays for science: Most scientific research is funded by government grants (e.g., from the National Science Foundation, the National Institutes of Health, etc.), companies doing research and development, and non-profit foundations.

Public and private sources have different priorities for funding scientific research. My nephew works on the development of a drug to stop Alzheimers for a biotechnology company formed by scientists and venture capitalists. Their research is motivated both to find better medicines for our collective health and to make money. As I approach 70, the prospect of preventing brain degeneration before it hits me is exciting. Their profit might extend my useful life.

Some privately funded scientific research is not in the public interest at all, such as the tobacco companies effort to deny the link to cancer, funneled through sciency-sounding propaganda organizations like the Heartland Institute.

The Republicans in Congress are not waging a war on all science; they quote from Heartlands fake science. They attack government-supported science because it might lead to government spending. For example, the discovery of lead in the water in Flint, Michigan, meant that old pipes must be replaced on 17,000 homes at an estimated cost of $7,500 each, totaling $127.5 million. Government-paid scientific research documented how lead affects babies brains, supported the creation of regulations which forced industry to stop using lead, compared the levels of lead in Flints water to experimental evidence on poisoning, and thus demonstrated the need for federal intervention.

Republicans in the Senate voted overwhelmingly to deny funding to deal with Flints crisis, but that effort lost by one vote. Congress authorized $170 million for Flint.

In the words of Understanding Science, Science affects your life every day in all sorts of different ways. Good public science saves lives and serves the public interest through government spending and government regulation. But those are Republican curse words. That is the deep secret behind the anti-science policies of Republicans in Congress and the White House. If they want to shrink government, they have to slow down or even stop science. They use tactics of obfuscation and delay. House Science Committee chair Lamar Smith attacked a 2015 study showing rising global temperatures. He used his old tactics, honed over decades in Congress: he demanded thousands of emails and other documents in search of malfeasance, misspent funds or corruption. He never found any, but he slowed down science he doesnt like.

This is not in our national interest. If we dont prepare for the worlds new climate, if we dont prevent health crises through regulation of pollutants, if we dont spend now on inconvenient science, we will have to spend much more later in economic and social costs. Peter Muennig, professor of public health at Columbia University, estimates that the two fewer healthy years of the 8,000 Flint children exposed to lead might cost American society $400 million.

The astrophysicist and TV explainer of science, Neil deGrasse Tyson, said, The good thing about science is that its true, whether or not you believe it.

The bad thing about Republican science politics is that our children and grandchildren will pay the price. Without science, its just fiction.

Olga Rodriguez | AP

http://myjournalcourier.com/wp-content/uploads/2017/05/web1_AP17112820985283.jpgOlga Rodriguez | AP

Steve Hochstadt is a writer, a gardener and a retired Illinois College professor of history. His column appears Tuesdays in the Journal-Courier and is available at stevehochstadt.blogspot.com.

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Commentary: Better living through chemistry - Jacksonville Journal Courier

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Xian (Taoism) – Wikipedia

Xian (Chinese: //; pinyin: xin; WadeGiles: hsien) is a Chinese word for an enlightened person, translatable in English as:

Xian semantically developed from meaning spiritual "immortality; enlightenment", to physical "immortality; longevity" involving methods such as alchemy, breath meditation, and T'ai chi ch'uan, and eventually to legendary and figurative "immortality".

The xian archetype is described by Victor H. Mair.

They are immune to heat and cold, untouched by the elements, and can fly, mounting upward with a fluttering motion. They dwell apart from the chaotic world of man, subsist on air and dew, are not anxious like ordinary people, and have the smooth skin and innocent faces of children. The transcendents live an effortless existence that is best described as spontaneous. They recall the ancient Indian ascetics and holy men known as i who possessed similar traits.1994:376

According to the Digital Dictionary of Buddhism, Chinese xian () can mean Sanskrit i (rishi "inspired sage in the Vedas").

The most famous Chinese compound of xin is Bxin ( "the Eight Immortals"). Other common words include xinrn ( sennin in Japanese, "immortal person; transcendent", see Xinrn Dng), xinrnzhng ( "immortal's palm; cactus"), xinn ( "immortal woman; female celestial; angel"), and shnxin ( "gods and immortals; divine immortal"). Besides humans, xin can also refer to supernatural animals. The mythological hlijng (lit. "fox spirit") "fox fairy; vixen; witch; enchantress" has an alternate name of hxin (lit. "fox immortal").

The etymology of xin remains uncertain. The circa 200 CE Shiming, a Chinese dictionary that provided word-pun "etymologies", defines xin () as "to get old and not die," and explains it as someone who qin ( "moves into") the mountains."

Edward H. Schafer (1966:204) defined xian as "transcendent, sylph (a being who, through alchemical, gymnastic and other disciplines, has achieved a refined and perhaps immortal body, able to fly like a bird beyond the trammels of the base material world into the realms of aether, and nourish himself on air and dew.)" Schafer noted xian was cognate to xian "soar up", qian "remove", and xianxian "a flapping dance movement"; and compared Chinese yuren "feathered man; xian" with English peri "a fairy or supernatural being in Persian mythology" (Persian pari from par "feather; wing").

Two linguistic hypotheses for the etymology of xian involve the Arabic language and Sino-Tibetan languages. Wu and Davis (1935:224) suggested the source was jinn, or jinni "genie" (from Arabic jinn). "The marvelous powers of the Hsien are so like those of the jinni of the Arabian Nights that one wonders whether the Arabic word, jinn, may not be derived from the Chinese Hsien." Axel Schuessler's etymological dictionary (2007:527) suggests a Sino-Tibetan connection between xin (Old Chinese *san or *sen) "'An immortal' men and women who attain supernatural abilities; after death they become immortals and deities who can fly through the air" and Tibetan gen < g-syen "shaman, one who has supernatural abilities, incl[uding] travel through the air".

The word xin is written with three characters , , or , which combine the logographic "radical" rn ( or "person; human") with two "phonetic" elements (see Chinese character classification). The oldest recorded xin character has a xin ("rise up; ascend") phonetic supposedly because immortals could "ascend into the heavens". (Compare qin "move; transfer; change" combining this phonetic and the motion radical.) The usual modern xin character , and its rare variant , have a shn ( "mountain") phonetic. For a character analysis, Schipper (1993:164) interprets "'the human being of the mountain,' or alternatively, 'human mountain.' The two explanations are appropriate to these beings: they haunt the holy mountains, while also embodying nature."

The Shijing (220/3) contains the oldest occurrence of the character , reduplicated as xinxin ( "dance lightly; hop about; jump around"), and rhymed with qin (). "But when they have drunk too much, Their deportment becomes light and frivolousThey leave their seats, and [] go elsewhere, They keep [] dancing and capering." (tr. James Legge)[1] Needham and Wang (1956:134) suggest xian was cognate with wu "shamanic" dancing. Paper (1995:55) writes, "the function of the term xian in a line describing dancing may be to denote the height of the leaps. Since, "to live for a long time" has no etymological relation to xian, it may be a later accretion."

The 121 CE Shuowen Jiezi, the first important dictionary of Chinese characters, does not enter except in the definition for (Wo Quan "name of an ancient immortal"). It defines as "live long and move away" and as "appearance of a person on a mountaintop".

This section chronologically reviews how Chinese texts describe xian "immortals; transcendents". While the early Zhuangzi, Chuci, and Liezi texts allegorically used xian immortals and magic islands to describe spiritual immortality, later ones like the Shenxian zhuan and Baopuzi took immortality literally and described esoteric Chinese alchemical techniques for physical longevity. On one the hand, neidan ( "internal alchemy") techniques included taixi ( "embryo respiration") breath control, meditation, visualization, sexual training, and Tao Yin exercises (which later evolved into Qigong and T'ai chi ch'uan). On the other hand, waidan ( "external alchemy") techniques for immortality included alchemical recipes, magic plants, rare minerals, herbal medicines, drugs, and dietetic techniques like inedia.

The earliest representations of Chinese immortals, dating from the Han Dynasty, portray them flying with feathery wings (the word yuren "feathered person" later meant "Daoist") or riding dragons. In Chinese art, xian are often pictured with symbols of immortality including the dragon, crane, fox, white deer, pine tree, peach, and mushroom.

Besides the following major Chinese texts, many others use both graphic variants of xian. Xian () occurs in the Chunqiu Fanlu, Fengsu Tongyi, Qian fu lun, Fayan, and Shenjian; xian () occurs in the Caizhong langji, Fengsu Tongyi, Guanzi, and Shenjian.

Two circa 3rd century BCE "Outer Chapters" of the Zhuangzi ( "[Book of] Master Zhuang") use the archaic character xian . Chapter 11 has a parable about "Cloud Chief" () and "Big Concealment" () that uses the Shijing compound xianxian ("dance; jump"):

Big Concealment said, "If you confuse the constant strands of Heaven and violate the true form of things, then Dark Heaven will reach no fulfillment. Instead, the beasts will scatter from their herds, the birds will cry all night, disaster will come to the grass and trees, misfortune will reach even to the insects. Ah, this is the fault of men who 'govern'!" "Then what should I do?" said Cloud Chief. "Ah," said Big Concealment, "you are too far gone! [] Up, up, stir yourself and be off!" Cloud Chief said, "Heavenly Master, it has been hard indeed for me to meet with youI beg one word of instruction!" "Well, thenmindnourishment!" said Big Concealment. "You have only to rest in inaction and things will transform themselves. Smash your form and body, spit out hearing and eyesight, forget you are a thing among other things, and you may join in great unity with the deep and boundless. Undo the mind, slough off spirit, be blank and soulless, and the ten thousand things one by one will return to the rootreturn to the root and not know why. Dark and undifferentiated chaosto the end of life none will depart from it. But if you try to know it, you have already departed from it. Do not ask what its name is, do not try to observe its form. Things will live naturally end of themselves." Cloud Chief said, "The Heavenly Master has favored me with this Virtue, instructed me in this Silence. All my life I have been looking for it, and now at last I have it!" He bowed his head twice, stood up, took his leave, and went away. (11, tr. Burton Watson 1968:122-3)

Chapter 12 uses xian when mythical Emperor Yao describes a shengren ( "sagely person").

The true sage is a quail at rest, a little fledgling at its meal, a bird in flight who leaves no trail behind. When the world has the Way, he joins in the chorus with all other things. When the world is without the Way, he nurses his Virtue and retires in leisure. And after a thousand years, should he weary of the world, he will leave it and [] ascend to [] the immortals, riding on those white clouds all the way up to the village of God. (12, tr. Watson 1968:130)

Without using the word xian, several Zhuangzi passages employ xian imagery, like flying in the clouds, to describe individuals with superhuman powers. For example, Chapter 1, within the circa 3rd century BCE "Inner Chapters", has two portrayals. First is this description of Liezi (below).

Lieh Tzu could ride the wind and go soaring around with cool and breezy skill, but after fifteen days he came back to earth. As far as the search for good fortune went, he didn't fret and worry. He escaped the trouble of walking, but he still had to depend on something to get around. If he had only mounted on the truth of Heaven and Earth, ridden the changes of the six breaths, and thus wandered through the boundless, then what would he have had to depend on? Therefore, I say, the Perfect Man has no self; the Holy Man has no merit; the Sage has no fame. (1, tr. Watson 1968:32)

Second is this description of a shenren ( "divine person").

He said that there is a Holy Man living on faraway [] Ku-she Mountain, with skin like ice or snow, and gentle and shy like a young girl. He doesn't eat the five grains, but sucks the wind, drinks the dew, climbs up on the clouds and mist, rides a flying dragon, and wanders beyond the Four Seas. By concentrating his spirit, he can protect creatures from sickness and plague and make the harvest plentiful. (1, tr. Watson 1968:33)

The authors of the Zhuangzi had a lyrical view of life and death, seeing them as complimentary aspects of natural changes. This is antithetical to the physical immortality (changshengbulao "live forever and never age") sought by later Daoist alchemists. Consider this famous passage about accepting death.

Chuang Tzu's wife died. When Hui Tzu went to convey his condolences, he found Chuang Tzu sitting with his legs sprawled out, pounding on a tub and singing. "You lived with her, she brought up your children and grew old," said Hui Tzu. "It should be enough simply not to weep at her death. But pounding on a tub and singingthis is going too far, isn't it?" Chuang Tzu said, "You're wrong. When she first died, do you think I didn't grieve like anyone else? But I looked back to her beginning and the time before she was born. Not only the time before she was born, but the time before she had a body. Not only the time before she had a body, but the time before she had a spirit. In the midst of the jumble of wonder and mystery a change took place and she had a spirit. Another change and she had a body. Another change and she was born. Now there's been another change and she's dead. It's just like the progression of the four seasons, spring, summer, fall, winter." "Now she's going to lie down peacefully in a vast room. If I were to follow after her bawling and sobbing, it would show that I don't understand anything about fate. So I stopped. (18, tr. Watson 1968:1912)

Alan Fox explains this anecdote about Zhuangzi's wife.

Many conclusions can be reached on the basis of this story, but it seems that death is regarded as a natural part of the ebb and flow of transformations which constitute the movement of Dao. To grieve over death, or to fear one's own death, for that matter, is to arbitrarily evaluate what is inevitable. Of course, this reading is somewhat ironic given the fact that much of the subsequent Daoist tradition comes to seek longevity and immortality, and bases some of their basic models on the Zhuangzi. (1995:100)

The 3rd-2nd century BCE Chuci ( "Lyrics of Chu") anthology of poems uses xian once and xian twice, reflecting the disparate origins of the text. These three contexts mention the legendary Daoist xian immortals Chi Song ( "Red Pine", see Kohn 1993:1424) and Wang Qiao (, or Zi Qiao ). In later Daoist hagiography, Chi Song was Lord of Rain under Shennong, the legendary inventor of agriculture; and Wang Qiao was a son of King Ling of Zhou (r. 571545 BCE), who flew away on a giant white bird, became an immortal and was never again seen.

The "Yuan You" ( "Far-off Journey") poem describes a spiritual journey into the realms of gods and immortals, frequently referring to Daoist myths and techniques.

My spirit darted forth and did not return to me, And my body, left tenantless, grew withered and lifeless. Then I looked into myself to strengthen my resolution, And sought to learn from where the primal spirit issues. In emptiness and silence I found serenity; In tranquil inaction I gained true satisfaction. I heard how once Red Pine had washed the world's dust off: I would model myself on the pattern he had left me. I honoured the wondrous powers of the [] Pure Ones, And those of past ages who had become [] Immortals. They departed in the flux of change and vanished from men's sight, Leaving a famous name that endures after them. (tr. Hawkes 1985:194)

The "Xi shi" ( "Sorrow for Troth Betrayed") resembles the "Yuan You", and both reflect Daoist ideas from the Han period. "Though unoriginal in theme," says Hawkes (1985:239), "its description of air travel, written in a pre-aeroplane age, is exhilarating and rather impressive."

We gazed down of the Middle Land [China] with its myriad people As we rested on the whirlwind, drifting about at random. In this way we came at last to the moor of Shao-yuan: There, with the other blessed ones, were Red Pine and Wang Qiao. The two Masters held zithers tuned in perfect concord: I sang the Qing Shang air to their playing. In tranquil calm and quiet enjoyment, Gently I floated, inhaling all the essences. But then I thought that this immortal life of [] the blessed, Was not worth the sacrifice of my home-returning. (tr. Hawkes 1985:240)

The "Ai shi ming" ( "Alas That My Lot Was Not Cast") describes a celestial journey similar to the previous two.

Far and forlorn, with no hope of return: Sadly I gaze in the distance, over the empty plain. Below, I fish in the valley streamlet; Above, I seek out [] holy hermits. I enter into friendship with Red Pine; I join Wang Qiao as his companion. We send the Xiao Yang in front to guide us; The White Tiger runs back and forth in attendance. Floating on the cloud and mist, we enter the dim height of heaven; Riding on the white deer we sport and take our pleasure. tr. Hawkes 1985:266)

The "Li Sao" ( "On Encountering Trouble"), the most famous Chuci poem, is usually interpreted as describing ecstatic flights and trance techniques of Chinese shamans. The above three poems are variations describing Daoist xian.

Some other Chuci poems refer to immortals with synonyms of xian. For instance, "Shou zhi" ( "Maintaining Resolution), uses zhenren ( "true person", tr. "Pure Ones" above in "Yuan You"), which Wang Yi's commentary glosses as zhen xianren ( "true immortal person").

I visited Fu Yue, bestriding a dragon, Joined in marriage with the Weaving Maiden, Lifted up Heaven's Net to capture evil, Drew the Bow of Heaven to shoot at wickedness, Followed the [] Immortals fluttering through the sky, Ate of the Primal Essence to prolong my life. (tr. Hawkes 1985:318)

The Liezi ( "[Book of] Master Lie"), which Louis Komjathy (2004:36) says "was probably compiled in the 3rd century CE (while containing earlier textual layers)", uses xian four times, always in the compound xiansheng ( "immortal sage").

Nearly half of Chapter 2 ("The Yellow Emperor") comes from the Zhuangzi, including this recounting of the above fable about Mount Gushe (, or Guye, or Miao Gushe ).

The Ku-ye mountains stand on a chain of islands where the Yellow River enters the sea. Upon the mountains there lives a Divine Man, who inhales the wind and drinks the dew, and does not eat the five grains. His mind is like a bottomless spring, his body is like a virgin's. He knows neither intimacy nor love, yet [] immortals and sages serve him as ministers. He inspires no awe, he is never angry, yet the eager and diligent act as his messengers. He is without kindness and bounty, but others have enough by themselves; he does not store and save, but he himself never lacks. The Yin and Yang are always in tune, the sun and moon always shine, the four seasons are always regular, wind and rain are always temperate, breeding is always timely, the harvest is always rich, and there are no plagues to ravage the land, no early deaths to afflict men, animals have no diseases, and ghosts have no uncanny echoes. (tr. Graham 1960:35)

Chapter 5 uses xiansheng three times in a conversation set between legendary rulers Tang () of the Shang Dynasty and Ji () of the Xia Dynasty.

T'ang asked again: 'Are there large things and small, long and short, similar and different?' 'To the East of the Gulf of Chih-li, who knows how many thousands and millions of miles, there is a deep ravine, a valley truly without bottom; and its bottomless underneath is named "The Entry to the Void". The waters of the eight corners and the nine regions, the stream of the Milky Way, all pour into it, but it neither shrinks nor grows. Within it there are five mountains, called Tai-y, Yan-chiao, Fang-hu, Ying-chou and P'eng-Iai. These mountains are thirty thousand miles high, and as many miles round; the tablelands on their summits extend for nine thousand miles. It is seventy thousand miles from one mountain to the next, but they are considered close neighbours. The towers and terraces upon them are all gold and jade, the beasts and birds are all unsullied white; trees of pearl and garnet always grow densely, flowering and bearing fruit which is always luscious, and those who eat of it never grow old and die. The men who dwell there are all of the race of [] immortal sages, who fly, too many to be counted, to and from one mountain to another in a day and a night. Yet the bases of the five mountains used to rest on nothing; they were always rising and falling, going and returning, with the ebb and flow of the tide, and never for a moment stood firm. The [] immortals found this troublesome, and complained about it to God. God was afraid that they would drift to the far West and he would lose the home of his sages. So he commanded Y-ch'iang to make fifteen [] giant turtles carry the five mountains on their lifted heads, taking turns in three watches, each sixty thousand years long; and for the first time the mountains stood firm and did not move. 'But there was a giant from the kingdom of the Dragon Earl, who came to the place of the five mountains in no more than a few strides. In one throw he hooked six of the turtles in a bunch, hurried back to his country carrying them together on his back, and scorched their bones to tell fortunes by the cracks. Thereupon two of the mountains, Tai-y and Yan-chiao, drifted to the far North and sank in the great sea; the [] immortals who were carried away numbered many millions. God was very angry, and reduced by degrees the size of the Dragon Earl's kingdom and the height of his subjects. At the time of Fu-hsi and Shen-nung, the people of this country were still several hundred feet high.' (tr. Graham 1960:978)

Penglai Mountain became the most famous of these five mythical peaks where the elixir of life supposedly grew, and is known as Horai in Japanese legends. The first emperor Qin Shi Huang sent his court alchemist Xu Fu on expeditions to find these plants of immortality, but he never returned (although by some accounts, he discovered Japan).

Holmes Welch (1957:8897) analyzed the beginnings of Daoism, sometime around the 4th-3rd centuries BCE, from four separate streams: philosophical Daoism (Laozi, Zhuangzi, Liezi), a "hygiene school" that cultivated longevity through breathing exercises and yoga, Chinese alchemy and Five Elements philosophy, and those who sought Penglai and elixirs of "immortality". This is what he concludes about xian.

It is my own opinion, therefore, that though the word hsien, or Immortal, is used by Chuang Tzu and Lieh Tzu, and though they attributed to their idealized individual the magic powers that were attributed to the hsien in later times, nonetheless the hsien ideal was something they did not believe ineither that it was possible or that it was good. The magic powers are allegories and hyperboles for the natural powers that come from identification with Tao. Spiritualized Man, P'eng-lai, and the rest are features of a genre which is meant to entertain, disturb, and exalt us, not to be taken as literal hagiography. Then and later, the philosophical Taoists were distinguished from all other schools of Taoism by their rejection of the pursuit of immortality. As we shall see, their books came to be adopted as scriptural authority by those who did practice magic and seek to become immortal. But it was their misunderstanding of philosophical Taoism that was the reason they adopted it. (Welch 1957:95)

The Shenxian zhuan ( Biographies of Spirit Immortals") is a hagiography of xian. Although it was traditionally attributed to Ge Hong (283343 CE), Komjathy (2004:43) says, "The received versions of the text contain some 100-odd hagiographies, most of which date from 6th-8th centuries at the earliest."

According to the Shenxian zhuan, there are four schools of immortality:

Q (Pneumas): Breath control and meditation. Those who belong to this school can

"...blow on water and it will flow against its own current for several paces; blow on fire, and it will be extinguished; blow at tigers or wolves, and they will crouch down and not be able to move; blow at serpents, and they will coil up and be unable to flee. If someone is wounded by a weapon, blow on the wound, and the bleeding will stop. If you hear of someone who has suffered a poisonous insect bite, even if you are not in his presence, you can, from a distance, blow and say in incantation over your own hand (males on the left hand, females on the right), and the person will at once be healed even if more than a hundred li away. And if you yourself are struck by a sudden illness, you have merely to swallow pneumas in three series of nine, and you will immediately recover. But the most essential thing [among such arts] is fetal breathing. Those who obtain [the technique of] fetal breathing become able to breathe without using their nose or mouth, as if in the womb, and this is the culmination of the way [of pneumatic cultivation]." (Campany 2002:21)

Fn (Diet): Ingestion of herbal compounds and abstention from the Sn Sh Fn (Three-Corpses food)Meats (raw fish, pork, dog, leeks, and scallions) and grains. The Shenxian zhuan uses this story to illustrate the importance of bigu "grain avoidance":

"During the reign of Emperor Cheng of the Han, hunters in the Zhongnan Mountains saw a person who wore no clothes, his body covered with black hair. Upon seeing this person, the hunters wanted to pursue and capture him, but the person leapt over gullies and valleys as if in flight, and so could not be overtaken. [But after being surrounded and captured, it was discovered this person was a 200 plus year old woman, who had once been a concubine of Qin Emperor Ziying. When he had surrendered to the 'invaders of the east', she fled into the mountains where she learned to subside on 'the resin and nuts of pines' from an old man. Afterwards, this diet 'enabled [her] to feel neither hunger nor thirst; in winter [she] was not cold, in summer [she] was not hot.'] The hunters took the woman back in. They offered her grain to eat. When she first smelled the stink of grain, she vomited, and only after several days could she tolerate it. After little more than two years of this [diet], her body hair fell out; she turned old and died. Had she not been caught by men, she would have become a transcendent." (Campany 2002:2223)

Fngzhng Zh Sh (Arts of the Bedchamber): Sexual yoga. (Campany 2002:3031) According to a discourse between the Yellow Emperor and the immortaless Sn (Plain Girl), one of the three daughters of Hsi Wang Mu,

The sexual behaviors between a man and woman are identical to how the universe itself came into creation. Like Heaven and Earth, the male and female share a parallel relationship in attaining an immortal existence. They both must learn how to engage and develop their natural sexual instincts and behaviors; otherwise the only result is decay and traumatic discord of their physical lives. However, if they engage in the utmost joys of sensuality and apply the principles of yin and yang to their sexual activity, their health, vigor, and joy of love will bear them the fruits of longevity and immortality. (Hsi 2002:99100)

The White Tigress Manual, a treatise on female sexual yoga, states,

A female can completely restore her youthfulness and attain immortality if she refrains from allowing just one or two men in her life from stealing and destroying her [sexual] essence, which will only serve in aging her at a rapid rate and bring about an early death. However, if she can acquire the sexual essence of a thousand males through absorption, she will acquire the great benefits of youthfulness and immortality. (Hsi 2001:48)

Dn ("Alchemy", literally "Cinnabar"): Elixir of Immortality.(Campany 2002:31)

The 4th century CE Baopuzi ( "[Book of] Master Embracing Simplicity"), which was written by Ge Hong, gives some highly detailed descriptions of xian.

The text lists three classes of immortals:

These titles were usually given to humans who had either not proven themselves worthy of or were not fated to become immortals. One such famous agent was Fei Changfang, who was eventually murdered by evil spirits because he lost his book of magic talismans. However, some immortals are written to have used this method in order to escape execution. (Campany 2002:5260)

Ge Hong wrote in his book The Master Who Embraces Simplicity,

The [immortals] Dark Girl and Plain Girl compared sexual activity as the intermingling of fire [yang/male] and water [yin/female], claiming that water and fire can kill people but can also regenerate their life, depending on whether or not they know the correct methods of sexual activity according to their nature. These arts are based on the theory that the more females a man copulates with, the greater benefit he will derive from the act. Men who are ignorant of this art, copulating with only one or two females during their life, will only suffice to bring about their untimely and early death. (Hsi 2001:48)

The Zhong L Chuan Dao Ji (/ "Anthology of the Transmission of the Dao from Zhong[li Quan] to L [Dongbin]") is associated with Zhongli Quan (2nd century CE?) and L Dongbin (9th century CE), two of the legendary Eight Immortals. It is part of the so-called Zhong-L () textual tradition of internal alchemy (neidan). Komjathy (2004:57) describes it as, "Probably dating from the late Tang (618906), the text is in question-and-answer format, containing a dialogue between L and his teacher Zhongli on aspects of alchemical terminology and methods."

The Zhong L Chuan Dao Ji lists five classes of immortals:

The ragama Stra, in an approach to Taoist teachings, discusses the characteristics of ten types of xian who exist between the world of devas ("gods") and that of human beings. This position, in Buddhist literature, is usually occupied by asuras ("Titans", "antigods"). These xian are not considered true cultivators of samadhi ("unification of mind"), as their methods differ from the practice of dhyna ("meditation").[2][3]

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Xian (Taoism) - Wikipedia

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Human Genetic Enhancements: A Transhumanist Perspective

1. What is Transhumanism?

Transhumanism is a loosely defined movement that has developed gradually over the past two decades. It promotes an interdisciplinary approach to understanding and evaluating the opportunities for enhancing the human condition and the human organism opened up by the advancement of technology. Attention is given to both present technologies, like genetic engineering and information technology, and anticipated future ones, such as molecular nanotechnology and artificial intelligence.1

The enhancement options being discussed include radical extension of human health-span, eradication of disease, elimination of unnecessary suffering, and augmentation of human intellectual, physical, and emotional capacities.2 Other transhumanist themes include space colonization and the possibility of creating superintelligent machines, along with other potential developments that could profoundly alter the human condition. The ambit is not limited to gadgets and medicine, but encompasses also economic, social, institutional designs, cultural development, and psychological skills and techniques.

Transhumanists view human nature as a work-in-progress, a half-baked beginning that we can learn to remold in desirable ways. Current humanity need not be the endpoint of evolution. Transhumanists hope that by responsible use of science, technology, and other rational means we shall eventually manage to become post-human, beings with vastly greater capacities than present human beings have.

Some transhumanists take active steps to increase the probability that they personally will survive long enough to become post-human, for example by choosing a healthy lifestyle or by making provisions for having themselves cryonically suspended in case of de-animation.3 In contrast to many other ethical outlooks, which in practice often reflect a reactionary attitude to new technologies, the transhumanist view is guided by an evolving vision to take a more active approach to technology policy. This vision, in broad strokes, is to create the opportunity to live much longer and healthier lives, to enhance our memory and other intellectual faculties, to refine our emotional experiences and increase our subjective sense of well-being, and generally to achieve a greater degree of control over our own lives. This affirmation of human potential is offered as an alternative to customary injunctions against playing God, messing with nature, tampering with our human essence, or displaying punishable hubris.

Transhumanism does not entail technological optimism. While future technological capabilities carry immense potential for beneficial deployments, they also could be misused to cause enormous harm, ranging all the way to the extreme possibility of intelligent life becoming extinct. Other potential negative outcomes include widening social inequalities or a gradual erosion of the hard-to-quantify assets that we care deeply about but tend to neglect in our daily struggle for material gain, such as meaningful human relationships and ecological diversity. Such risks must be taken very seriously, as thoughtful transhumanists fully acknowledge.4

Transhumanism has roots in secular humanist thinking, yet is more radical in that it promotes not only traditional means of improving human nature, such as education and cultural refinement, but also direct application of medicine and technology to overcome some of our basic biological limits.

2. A Core Transhumanist Value: Exploring the Post-human Realm

The range of thoughts, feelings, experiences, and activities that are accessible to human organisms presumably constitute only a tiny part of what is possible. There is no reason to think that the human mode of being is any more free of limitations imposed by our biological nature than are the modes of being of other animals. Just as chimpanzees lack the brainpower to understand what it is like to be human, so too do we lack the practical ability to form a realistic intuitive understanding of what it would be like to be post-human.

This point is distinct from any principled claims about impossibility. We need not assert that post-humans would not be Turing computable or that their concepts could not be expressed by any finite sentences in human language. The impossibility is more like the impossibility for us to visualize a twenty-dimensional hypersphere or to read, with perfect recollection and understanding, every book in the Library of Congress. Our own current mode of being, therefore, spans but a minute subspace of what is possible or permitted by the physical constraints of the universe. It is not farfetched to suppose that there are parts of this larger space that represent extremely valuable ways of living, feeling, and thinking.

We can conceive of aesthetic and contemplative pleasures whose blissfulness vastly exceeds what any human being has yet experienced. We can imagine beings that reach a much greater level of personal development and maturity than current human beings do, because they have the opportunity to live for hundreds or thousands of years with full bodily and psychic vigor. We can conceive of beings that are much smarter than us, that can read books in seconds, that are much more brilliant philosophers than we are, that can create artworks, which, even if we could understand them only on the most superficial level, would strike us as wonderful masterpieces. We can imagine love that is stronger, purer, and more secure than any human being has yet harbored. Our everyday intuitions about values are constrained by the narrowness of our experience and the limitations of our powers of imagination. We should leave room in our thinking for the possibility that as we develop greater capacities, we shall come to discover values that will strike us as being of a far higher order than those we can realize as un-enhanced biological humans beings.

The conjecture that there are greater values than we can currently fathom does not imply that values are not defined in terms of our current dispositions. Take, for example, a dispositional theory of value such as the one described by David Lewis.5 According to Lewiss theory, something is a value for you if and only if you would want to want it if you were perfectly acquainted with it and you were thinking and deliberating as clearly as possible about it. On this view, there may be values that we do not currently want, and that we do not even currently want to want, because we may not be perfectly acquainted with them or because we are not ideal deliberators. Some values pertaining to certain forms of post-human existence may well be of this sort; they may be values for us now, and they may be so in virtue of our current dispositions, and yet we may not be able to fully appreciate them with our current limited deliberative capacities and our lack of the receptive faculties required for full acquaintance with them. This point is important because it shows that the transhumanist view that we ought to explore the realm of post-human values does not entail that we should forego our current values. The post-human values can be our current values, albeit ones that we have not yet clearly comprehended. Transhumanism does not require us to say that we should favor post-human beings over human beings, but that the right way of favoring human beings is by enabling us to realize our ideals better and that some of our ideals may well be located outside the space of modes of being that are accessible to us with our current biological constitution.

We can overcome many of our biological limitations. It is possible that there are some limitations that are impossible for us to transcend, not only because of technological difficulties but on metaphysical grounds. Depending on what our views are about what constitutes personal identity, it could be that certain modes of being, while possible, are not possible for us, because any being of such a kind would be so different from us that they could not be us. Concerns of this kind are familiar from theological discussions of the afterlife. In Christian theology, some souls will be allowed by God to go to heaven after their time as corporal creatures is over. Before being admitted to heaven, the souls would undergo a purification process in which they would lose many of their previous bodily attributes. Skeptics may doubt that the resulting minds would be sufficiently similar to our current minds for it to be possible for them to be the same person. A similar predicament arises within transhumanism: if the mode of being of a post-human being is radically different from that of a human being, then we may doubt whether a post-human being could be the same person as a human being, even if the post-human being originated from a human being.

We can, however, envision many enhancements that would not make it impossible for the post-transformation someone to be the same person as the pre-transformation person. A person could obtain considerable increased life expectancy, intelligence, health, memory, and emotional sensitivity, without ceasing to exist in the process. A persons intellectual life can be transformed radically by getting an education. A persons life expectancy can be extended substantially by being unexpectedly cured from a lethal disease. Yet these developments are not viewed as spelling the end of the original person. In particular, it seems that modifications that add to a persons capacities can be more substantial than modifications that subtract, such as brain damage. If most of someone currently is, including her most important memories, activities, and feelings, is preserved, then adding extra capacities on top of that would not easily cause the person to cease to exist.

Preservation of personal identity, especially if this notion is given a narrow construal, is not everything. We can value other things than ourselves, or we might regard it as satisfactory if some parts or aspects of ourselves survive and flourish, even if that entails giving up some parts of ourselves such that we no longer count as being the same person. Which parts of ourselves we might be willing to sacrifice may not become clear until we are more fully acquainted with the full meaning of the options. A careful, incremental exploration of the post-human realm may be indispensable for acquiring such an understanding, although we may also be able to learn from each others experiences and from works of the imagination. Additionally, we may favor future people being posthuman rather than human, if the posthumans would lead lives more worthwhile than the alternative humans would. Any reasons stemming from such considerations would not depend on the assumption that we ourselves could become posthuman beings.

Transhumanism promotes the quest to develop further so that we can explore hitherto inaccessible realms of value. Technological enhancement of human organisms is a means that we ought to pursue to this end. There are limits to how much can be achieved by low-tech means such as education, philosophical contemplation, moral self-scrutiny and other such methods proposed by classical philosophers with perfectionist leanings, including Plato, Aristotle, and Nietzsche, or by means of creating a fairer and better society, as envisioned by social reformists such as Marx or Martin Luther King. This is not to denigrate what we can do with the tools we have today. Yet ultimately, transhumanists hope to go further.

3. The Morality of Human Germ-Line Genetic Engineering

Most potential human enhancement technologies have so far received scant attention in the ethics literature. One exception is genetic engineering, the morality of which has been extensively debated in recent years. To illustrate how the transhumanist approach can be applied to particular technologies, we shall therefore now turn to consider the case of human germ-line genetic enhancements.

Certain types of objection against germ-line modifications are not accorded much weight by a transhumanist interlocutor. For instance, objections that are based on the idea that there is something inherently wrong or morally suspect in using science to manipulate human nature are regarded by transhumanists as wrongheaded. Moreover, transhumanists emphasize that particular concerns about negative aspects of genetic enhancements, even when such concerns are legitimate, must be judged against the potentially enormous benefits that could come from genetic technology successfully employed.6 For example, many commentators worry about the psychological effects of the use of germ-line engineering. The ability to select the genes of our children and to create so-called designer babies will, it is claimed, corrupt parents, who will come to view their children as mere products.7 We will then begin to evaluate our offspring according to standards of quality control, and this will undermine the ethical ideal of unconditional acceptance of children, no matter what their abilities and traits. Are we really prepared to sacrifice on the altar of consumerism even those deep values that are embodied in traditional relationships between child and parents? Is the quest for perfection worth this cultural and moral cost? A transhumanist should not dismiss such concerns as irrelevant. Transhumanists recognize that the depicted outcome would be bad. We do not want parents to love and respect their children less. We do not want social prejudice against people with disabilities to get worse. The psychological and cultural effects of commodifying human nature are potentially important.

But such dystopian scenarios are speculations. There is no firm ground for believing that the alleged consequences would actually happen. What relevant evidence we have, for instance regarding the treatment of children who have been conceived through the use of in vitro fertilization or embryo screening, suggests that the pessimistic prognosis is alarmist. Parents will in fact love and respect their children even when artificial means and conscious choice play a part in procreation.

We might speculate, instead, that germ-line enhancements will lead to more love and parental dedication. Some mothers and fathers might find it easier to love a child who, thanks to enhancements, is bright, beautiful, healthy, and happy. The practice of germ-line enhancement might lead to better treatment of people with disabilities, because a general demystification of the genetic contributions to human traits could make it clearer that people with disabilities are not to blame for their disabilities and a decreased incidence of some disabilities could lead to more assistance being available for the remaining affected people to enable them to live full, unrestricted lives through various technological and social supports. Speculating about possible psychological or cultural effects of germ-line engineering can therefore cut both ways. Good consequences no less than bad ones are possible. In the absence of sound arguments for the view that the negative consequences would predominate, such speculations provide no reason against moving forward with the technology.

Ruminations over hypothetical side-effects may serve to make us aware of things that could go wrong so that we can be on the lookout for untoward developments. By being aware of the perils in advance, we will be in a better position to take preventive countermeasures. For instance, if we think that some people would fail to realize that a human clone would be a unique person deserving just as much respect and dignity as any other human being, we could work harder to educate the public on the inadequacy of genetic determinism. The theoretical contributions of well-informed and reasonable critics of germ-line enhancement could indirectly add to our justification for proceeding with germ-line engineering. To the extent that the critics have done their job, they can alert us to many of the potential untoward consequences of germ-line engineering and contribute to our ability to take precautions, thus improving the odds that the balance of effects will be positive. There may well be some negative consequences of human germ-line engineering that we will not forestall, though of course the mere existence of negative effects is not a decisive reason not to proceed. Every major technology has some negative consequences. Only after a fair comparison of the risks with the likely positive consequences can any conclusion based on a cost-benefit analysis be reached.

In the case of germ-line enhancements, the potential gains are enormous. Only rarely, however, are the potential gains discussed, perhaps because they are too obvious to be of much theoretical interest. By contrast, uncovering subtle and non-trivial ways in which manipulating our genome could undermine deep values is philosophically a lot more challenging. But if we think about it, we recognize that the promise of genetic enhancements is anything but insignificant. Being free from severe genetic diseases would be good, as would having a mind that can learn more quickly, or having a more robust immune system. Healthier, wittier, happier people may be able to reach new levels culturally. To achieve a significant enhancement of human capacities would be to embark on the transhuman journey of exploration of some of the modes of being that are not accessible to us as we are currently constituted, possibly to discover and to instantiate important new values. On an even more basic level, genetic engineering holds great potential for alleviating unnecessary human suffering. Every day that the introduction of effective human genetic enhancement is delayed is a day of lost individual and cultural potential, and a day of torment for many unfortunate sufferers of diseases that could have been prevented. Seen in this light, proponents of a ban or a moratorium on human genetic modification must take on a heavy burden of proof in order to have the balance of reason tilt in their favor. Transhumanists conclude that the challenge has not been met.

4. Should Human Reproduction be Regulated?

One way of going forward with genetic engineering is to permit everything, leaving all choices to parents. While this attitude may be consistent with transhumanism, it is not the best transhumanist approach. One thing that can be said for adopting a libertarian stance in regard to human reproduction is the sorry track record of socially planned attempts to improve the human gene pool. The list of historical examples of state intervention in this domain ranges from the genocidal horrors of the Nazi regime, to the incomparably milder but still disgraceful semi-coercive sterilization programs of mentally impaired individuals favored by many well-meaning socialists in the past century, to the controversial but perhaps understandable program of the current Chinese government to limit population growth. In each case, state policies interfered with the reproductive choices of individuals. If parents had been left to make the choices for themselves, the worst transgressions of the eugenics movement would not have occurred. Bearing this in mind, we ought to think twice before giving our support to any proposal that would have the state regulate what sort of children people are allowed to have and the methods that may be used to conceive them.8

We currently permit governments to have a role in reproduction and child-rearing and we may reason by extension that there would likewise be a role in regulating the application of genetic reproductive technology. State agencies and regulators play a supportive and supervisory role, attempting to promote the interests of the child. Courts intervene in cases of child abuse or neglect. Some social policies are in place to support children from disadvantaged backgrounds and to ameliorate some of the worst inequities suffered by children from poor homes, such as through the provision of free schooling. These measures have analogues that apply to genetic enhancement technologies. For example, we ought to outlaw genetic modifications that are intended to damage the child or limit its opportunities in life, or that are judged to be too risky. If there are basic enhancements that would be beneficial for a child but that some parents cannot afford, then we should consider subsidizing those enhancements, just as we do with basic education. There are grounds for thinking that the libertarian approach is less appropriate in the realm of reproduction than it is in other areas. In reproduction, the most important interests at stake are those of the child-to-be, who cannot give his or her advance consent or freely enter into any form of contract. As it is, we currently approve of many measures that limit parental freedoms. We have laws against child abuse and child neglect. We have obligatory schooling. In some cases, we can force needed medical treatment on a child, even against the wishes of its parents.

There is a difference between these social interventions with regard to children and interventions aimed at genetic enhancements. While there is a consensus that nobody should be subjected to child abuse and that all children should have at least a basic education and should receive necessary medical care, it is unlikely that we will reach an agreement on proposals for genetic enhancements any time soon. Many parents will resist such proposals on principled grounds, including deep-seated religious or moral convictions. The best policy for the foreseeable future may therefore be to not legally require any genetic enhancements, except perhaps in extreme cases for which there is no alternative treatment. Even in such cases, it is dubious that the social climate in many countries is ready for mandatory genetic interventions.

The scope for ethics and public policy, however, extend far beyond the passing of laws requiring or banning specific interventions. Even if a given enhancement option is neither outlawed nor legally required, we may still seek to discourage or encourage its use in a variety of ways. Through subsidies and taxes, research-funding policies, genetic counseling practices and guidelines, laws regulating genetic information and genetic discrimination, provision of health care services, regulation of the insurance industry, patent law, education, and through the allocation of social approbation and disapproval, we may influence the direction in which particular technologies are applied. We may appropriately ask, with regard to genetic enhancement technologies, which types of applications we ought to promote or discourage.

5. Which Modifications Should Be Promoted and which Discouraged?

An externality, as understood by economists, is a cost or a benefit of an action that is not carried by a decision-maker. An example of a negative externality might be found in a firm that lowers its production costs by polluting the environment. The firm enjoys most of the benefits while escaping the costs, such as environmental degradation, which may instead paid by people living nearby. Externalities can also be positive, as when people put time and effort into creating a beautiful garden outside their house. The effects are enjoyed not exclusively by the gardeners but spill over to passersby. As a rule of thumb, sound social policy and social norms would have us internalize many externalities so that the incentives of producers more closely match the social value of production. We may levy a pollution tax on the polluting firm, for instance, and give our praise to the home gardeners who beautify the neighborhood.

Genetic enhancements aimed at the obtainment of goods that are desirable only in so far as they provide a competitive advantage tend to have negative externalities. An example of such a positional good, as economists call them, is stature. There is evidence that being tall is statistically advantageous, at least for men in Western societies. Taller men earn more money, wield greater social influence, and are viewed as more sexually attractive. Parents wanting to give their child the best possible start in life may rationally choose a genetic enhancement that adds an inch or two to the expected length of their offspring. Yet for society as a whole, there seems to be no advantage whatsoever in people being taller. If everybody grew two inches, nobody would be better off than they were before. Money spent on a positional good like length has little or no net effect on social welfare and is therefore, from societys point of view, wasted.

Health is a very different type of good. It has intrinsic benefits. If we become healthier, we are personally better off and others are not any worse off. There may even be a positive externality of enhancing ours own health. If we are less likely to contract a contagious disease, others benefit by being less likely to get infected by us. Being healthier, you may also contribute more to society and consume less of publicly funded healthcare.

If we were living in a simple world where people were perfectly rational self-interested economic agents and where social policies had no costs or unintended effects, then the basic policy prescription regarding genetic enhancements would be relatively straightforward. We should internalize the externalities of genetic enhancements by taxing enhancements that have negative externalities and subsidizing enhancements that have positive externalities. Unfortunately, crafting policies that work well in practice is considerably more difficult. Even determining the net size of the externalities of a particular genetic enhancement can be difficult. There is clearly an intrinsic value to enhancing memory or intelligence in as much as most of us would like to be a bit smarter, even if that did not have the slightest effect on our standing in relation to others. But there would also be important externalities, both positive and negative. On the negative side, others would suffer some disadvantage from our increased brainpower in that their own competitive situation would be worsened. Being more intelligent, we would be more likely to attain high-status positions in society, positions that would otherwise have been enjoyed by a competitor. On the positive side, others might benefit from enjoying witty conversations with us and from our increased taxes.

If in the case of intelligence enhancement the positive externalities outweigh the negative ones, then a prima facie case exists not only for permitting genetic enhancements aimed at increasing intellectual ability, but for encouraging and subsidizing them too. Whether such policies remain a good idea when all practicalities of implementation and political realities are taken into account is another matter. But at least we can conclude that an enhancement that has both significant intrinsic benefits for an enhanced individual and net positive externalities for the rest of society should be encouraged. By contrast, enhancements that confer only positional advantages, such as augmentation of stature or physical attractiveness, should not be socially encouraged, and we might even attempt to make a case for social policies aimed at reducing expenditure on such goods, for instance through a progressive tax on consumption.9

6. The Issue of Equality

One important kind of externality in germ-line enhancements is their effects on social equality. This has been a focus for many opponents of germ-line genetic engineering who worry that it will widen the gap between haves and have-nots. Today, children from wealthy homes enjoy many environmental privileges, including access to better schools and social networks. Arguably, this constitutes an inequity against children from poor homes. We can imagine scenarios where such inequities grow much larger thanks to genetic interventions that only the rich can afford, adding genetic advantages to the environmental advantages already benefiting privileged children. We could even speculate about the members of the privileged stratum of society eventually enhancing themselves and their offspring to a point where the human species, for many practical purposes, splits into two or more species that have little in common except a shared evolutionary history.10 The genetically privileged might become ageless, healthy, super-geniuses of flawless physical beauty, who are graced with a sparkling wit and a disarmingly self-deprecating sense of humor, radiating warmth, empathetic charm, and relaxed confidence. The non-privileged would remain as people are today but perhaps deprived of some their self-respect and suffering occasional bouts of envy. The mobility between the lower and the upper classes might disappear, and a child born to poor parents, lacking genetic enhancements, might find it impossible to successfully compete against the super-children of the rich. Even if no discrimination or exploitation of the lower class occurred, there is still something disturbing about the prospect of a society with such extreme inequalities.

While we have vast inequalities today and regard many of these as unfair, we also accept a wide range of inequalities because we think that they are deserved, have social benefits, or are unavoidable concomitants to free individuals making their own and sometimes foolish choices about how to live their lives. Some of these justifications can also be used to exonerate some inequalities that could result from germ-line engineering. Moreover, the increase in unjust inequalities due to technology is not a sufficient reason for discouraging the development and use of the technology. We must also consider its benefits, which include not only positive externalities but also intrinsic values that reside in such goods as the enjoyment of health, a soaring mind, and emotional well-being.

We can also try to counteract some of the inequality-increasing tendencies of enhancement technology with social policies. One way of doing so would be by widening access to the technology by subsidizing it or providing it for free to children of poor parents. In cases where the enhancement has considerable positive externalities, such a policy may actually benefit everybody, not just the recipients of the subsidy. In other cases, we could support the policy on the basis of social justice and solidarity.

Even if all genetic enhancements were made available to everybody for free, however, this might still not completely allay the concern about inequity. Some parents might choose not to give their children any enhancements. The children would then have diminished opportunities through no fault of their own. It would be peculiar, however, to argue that governments should respond to this problem by limiting the reproductive freedom of the parents who wish to use genetic enhancements. If we are willing to limit reproductive freedom through legislation for the sake of reducing inequities, then we might as well make some enhancements obligatory for all children. By requiring genetic enhancements for everybody to the same degree, we would not only prevent an increase in inequalities but also reap the intrinsic benefits and the positive externalities that would come from the universal application of enhancement technology. If reproductive freedom is regarded as too precious to be curtailed, then neither requiring nor banning the use of reproductive enhancement technology is an available option. In that case, we would either have to tolerate inequities as a price worth paying for reproductive freedom or seek to remedy the inequities in ways that do not infringe on reproductive freedom.

All of this is based on the hypothesis that germ-line engineering would in fact increase inequalities if left unregulated and no countermeasures were taken. That hypothesis might be false. In particular, it might turn out to be technologically easier to cure gross genetic defects than to enhance an already healthy genetic constitution. We currently know much more about many specific inheritable diseases, some of which are due to single gene defects, than we do about the genetic basis of talents and desirable qualities such as intelligence and longevity, which in all likelihood are encoded in complex constellations of multiple genes. If this turns out to be the case, then the trajectory of human genetic enhancement may be one in which the first thing to happen is that the lot of the genetically worst-off is radically improved, through the elimination of diseases such as Tay Sachs, Lesch-Nyhan, Downs Syndrome, and early-onset Alzheimers disease. This would have a major leveling effect on inequalities, not primarily in the monetary sense, but with respect to the even more fundamental parameters of basic opportunities and quality of life.

7. Are Germ-Line Interventions Wrong Because They Are Irreversible?

Another frequently heard objection against germ-line genetic engineering is that it would be uniquely hazardous because the changes it would bring are irreversible and would affect all generations to come. It would be highly irresponsible and arrogant of us to presume we have the wisdom to make decisions about what should be the genetic constitutions of people living many generations hence. Human fallibility, on this objection, gives us good reason not to embark on germ-line interventions. For our present purposes, we can set aside the issue of the safety of the procedure, understood narrowly, and stipulate that the risk of medical side-effects has been reduced to an acceptable level. The objection under consideration concerns the irreversibility of germ-line interventions and the lack of predictability of its long-term consequences; it forces us to ask if we possess the requisite wisdom for making genetic choices on behalf of future generations.

Human fallibility is not a conclusive ground for resisting germ-line genetic enhancements. The claim that such interventions would be irreversible is incorrect. Germ-line interventions can be reversed by other germ-line interventions. Moreover, considering that technological progress in genetics is unlikely to grind to an abrupt halt any time soon, we can count on future generations being able to reverse our current germ-line interventions even more easily than we can currently implement them. With advanced genetic technology, it might even be possible to reverse many germ-line modifications with somatic gene therapy, or with medical nanotechnology.11 Technologically, germ-line changes are perfectly reversible by future generations.

It is possible that future generations might choose to retain the modifications that we make. If that turns out to be the case, then the modifications, while not irreversible, would nevertheless not actually be reversed. This might be a good thing. The possibility of permanent consequences is not an objection against germ-line interventions any more than it is against social reforms. The abolition of slavery and the introduction of general suffrage might never be reversed; indeed, we hope they will not be. Yet this is no reason for people to have resisted the reforms. Likewise, the potential for everlasting consequences, including ones we cannot currently reliably forecast, in itself constitutes no reason to oppose genetic intervention. If immunity against horrible diseases and enhancements that expand the opportunities for human growth are passed on to subsequent generations in perpetuo, it would be a cause for celebration, not regret.

There are some kinds of changes that we need be particularly careful about. They include modifications of the drives and motivations of our descendants. For example, there are obvious reasons why we might think it worthwhile to seek to reduce our childrens propensity to violence and aggression. We would have to take care, however, that we do not do this in a way that would make future people overly submissive or complacent. We can conceive of a dystopian scenario along the lines of Brave New World, in which people are leading shallow lives but have been manipulated to be perfectly content with their sub-optimal existence. If the people transferred their shallow values to their children, humanity could get permanently stuck in a not-very-good state, having foolishly changed itself to lack any desire to strive for something better. This outcome would be dystopian because a permanent cap on human development would destroy the transhumanist hope of exploring the post-human realm. Transhumanists therefore place an emphasis on modifications which, in addition to promoting human well-being, also open more possibilities than they close and which increase our ability to make subsequent choices wisely. Longer active lifespans, better memory, and greater intellectual capacities are plausible candidates for enhancements that would improve our ability to figure out what we ought to do next. They would be a good place to start.12

Notes

1. See Eric K. Drexler, Nanosystems: Molecular Machinery, Manufacturing, and Computation (New York: John Wiley & Sons, Inc., 1992); Ray Kurzweil, The Age of Spiritual Machines: When Computers Exceed Human Intelligence (New York: Viking, 1999); Hans Moravec, Robot: Mere Machine to Transcendent Mind. (New York: Oxford University Press, 1999).

2. See Robert A. Freitas Jr., Nanomedicine, Volume 1: Basic Capabilities (Georgetown, Tex.: Landes Bioscience, 1999).

3. See Robert Ettinger, The Prospect of Immortality (New York: Doubleday, 1964); James Hughes, The Future of Death: Cryonics and the Telos of Liberal Individualism, Journal of Evolution and Technology 6 (2001).

4. See Eric K. Drexler, Engines of Creation: The Coming Era of Nanotechnology (London: Fourth Estate, 1985).

5. See David Lewis, Dispositional Theories of Value, Proceedings of the Aristotelian Society Supp. 63 (1989).

6. See Erik Parens, ed., Enhancing Human Traits: Ethical and Social Implications. (Washington, D. C: Georgetown University Press, 1998).

7. See Leon Kass, Life, Liberty, and Defense of Dignity: The Challenge for Bioethics (San Francisco: Encounter Books, 2002).

8. See Jonathan Glover, What Sort of People Should There Be? (New York: Penguin, 1984); Gregory Stock, Redesigning Humans: Our Inevitable Genetic Future (New York, Houghton Mifflin, 2002); and Allen Buchanan et al., From Chance to Choice: Genetics & Justice (Cambridge, England: Cambridge University Press, 2002).

9. See Robert H. Frank, Luxury Fever: Why Money Fails to Satisfy in an Era of Excess (New York: Free Press, 1999).

10. Cf. Lee M. Silver, Remaking Eden: How Genetic Engineering and Cloning will Transform the American Family (New York: Avon Books, 1997); and Nancy Kress, Beggars in Spain (Avon Books, 1993).

11. See Freitas, op. cit.

12. For their helpful comments I am grateful to Heather Bradshaw, Robert A. Freitas Jr., James Hughes, Gerald Lang, Matthew Liao, Thomas Magnell, David Rodin, Jeffrey Soreff, Mike Treder, Mark Walker, Michael Weingarten, and an anonymous referee of the Journal of Value Inquiry.

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Human Genetic Enhancements: A Transhumanist Perspective

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What is Transhumanism?

The human desire to acquire posthuman attributes is as ancient as the human species itself. Humans have always sought to expand the boundaries of their existence, be it ecologically, geographically, or mentally. There is a tendency in at least some individuals always to try to find a way around every limitation and obstacle.

Ceremonial burial and preserved fragments of religious writings show that prehistoric humans were deeply disturbed by the death of their loved ones and sought to reduce the cognitive dissonance by postulating an afterlife. Yet, despite the idea of an afterlife, people still endeavored to extend life. In the Sumerian Epic of Gilgamesh (approx. 2000 B.C.), a king embarks on a quest to find an herb that can make him immortal. Its worth noting that it was assumed both that mortality was not inescapable in principle, and that there existed (at least mythological) means of overcoming it. That people really strove to live longer and richer lives can also be seen in the development of systems of magic and alchemy; lacking scientific means of producing an elixir of life, one resorted to magical means. This strategy was adopted, for example, by the various schools of esoteric Taoism in China, which sought physical immortality and control over or harmony with the forces of nature.

The Greeks were ambivalent about humans transgressing our natural confines. On the one hand, they were fascinated by the idea. We see it in the myth of Prometheus, who stole the fire from Zeus and gave it to the humans, thereby permanently improving the human condition. And in the myth of Daedalus, the gods are repeatedly challenged, quite successfully, by a clever engineer and artist, who uses non-magical means to extend human capabilities. On the other hand, there is also the concept of hubris: that some ambitions are off-limit and would backfire if pursued. In the end, Daedalus enterprise ends in disaster (not, however, because it was punished by the gods but owing entirely to natural causes).

Greek philosophers made the first, stumbling attempts to create systems of thought that were based not purely on faith but on logical reasoning. Socrates and the sophists extended the application of critical thinking from metaphysics and cosmology to include the study of ethics and questions about human society and human psychology. Out of this inquiry arose cultural humanism, a very important current throughout the history of Western science, political theory, ethics, and law.

In the Renaissance, human thinking was awoken from medieval otherworldliness and the scholastic modes of reasoning that had predominated for a millennium, and the human being and the natural world again became legitimate objects of study. Renaissance humanism encouraged people to rely on their own observations and their own judgment rather than to defer in every matter to religious authorities. Renaissance humanism also created the ideal of the well-rounded personality, one that is highly developed scientifically, morally, culturally, and spiritually. A milestone is Giovanni Pico della Mirandolas Oration on the Dignity of Man (1486), which states that man does not have a ready form but that it is mans task to form himself. And crucially, modern science began to take form then, through the works of Copernicus, Kepler, and Galileo.

The Age of Enlightenment can be said to have started with the publication of Francis Bacons Novum Organum, the new tool (1620), in which he proposes a scientific methodology based on empirical investigation rather than a priori reasoning. Bacon advocates the project of effecting all things possible, by which he meant the achievement of mastery over nature in order to improve the condition of human beings. The heritage from the Renaissance combines with the influences of Isaac Newton, Thomas Hobbes, John Locke, Immanuel Kant, Marquis de Condorcet, and others to form the basis for rational humanism, which emphasizes science and critical reasoning rather than revelation and religious authority as ways of learning about the natural world and the destiny and nature of man and of providing a grounding for morality. Transhumanism traces its roots to this rational humanism.

In the 18th and 19th centuries we begin to see glimpses of the idea that even humans themselves can be developed through the appliance of science. Benjamin Franklin and Voltaire speculated about extending human life span through medical science. Especially after Darwins theory of evolution, atheism or agnosticism came to be seen as increasingly attractive alternatives. However, the optimism of the late 19th century often degenerated into narrow-minded positivism and the belief that progress was automatic. When this view collided with reality, some people reacted by turning to irrationalism, concluding that since reason was not sufficient, it was worthless. This resulted in the anti-technological, anti-intellectual sentiments whose sequelae we can still witness today in some postmodernist writers, in the New Age movement, and among the neo-Luddite wing of the anti-globalization agitators.

A significant stimulus in the formation of transhumanism was the essay Daedalus: Science and the Future (1923) by the British biochemist J. B. S. Haldane, in which he discusses how scientific and technological findings may come to affect society and improve the human condition. This essay set off a chain reaction of future-oriented discussions, including The World, the Flesh and the Devil by J. D. Bernal (1929), which speculates about space colonization and bionic implants as well as mental improvements through advanced social science and psychology; the works of Olaf Stapledon; and the essay Icarus: the Future of Science (1924) by Bertrand Russell, who took a more pessimistic view, arguing that without more kindliness in the world, technological power will mainly serve to increase mens ability to inflict harm on one another. Science fiction authors such as H. G. Wells and Olaf Stapledon also got many people thinking about the future evolution of the human race. One frequently cited work is Aldous Huxleys Brave New World (1932), a dystopia where psychological conditioning, promiscuous sexuality, biotechnology, and opiate drugs are used to keep the population placid and contented in a static, totalitarian society ruled by an elite consisting of ten world controllers. Huxleys novel warns of the dehumanizing potential of technology being used to arrest growth and to diminish the scope of human nature rather than enhance it.

The Second World War changed the direction of some of those currents that result in todays transhumanism. The eugenics movement, which had previously found advocates not only among racists on the extreme right but also among socialists and progressivist social democrats, was thoroughly discredited. The goal of creating a new and better world through a centrally imposed vision became taboo and pass; and the horrors of the Stalinist Soviet Union again underscored the dangers of such an approach. Mindful of these historical lessons, transhumanists are often deeply suspicious of collectively orchestrated change, arguing instead for the right of individuals to redesign themselves and their own descendants.

In the postwar era, optimistic futurists tended to direct their attention more toward technological progress, such as space travel, medicine, and computers. Science began to catch up with speculation. Transhumanist ideas during this period were discussed and analyzed chiefly in the literary genre of science fiction. Authors such as Arthur C. Clarke, Isaac Asimov, Robert Heinlein, Stanislaw Lem, and later Bruce Sterling, Greg Egan, and Vernor Vinge have explored various aspects of transhumanism in their writings and contributed to its proliferation.

Robert Ettinger played an important role in giving transhumanism its modern form. The publication of his book The Prospect of Immortality in 1964 led to the creation of the cryonics movement. Ettinger argued that since medical technology seems to be constantly progressing, and since chemical activity comes to a complete halt at low temperatures, it should be possible to freeze a person today and preserve the body until such a time when technology is advanced enough to repair the freezing damage and reverse the original cause of deanimation. In a later work, Man into Superman (1972), he discussed a number of conceivable improvements to the human being, continuing the tradition started by Haldane and Bernal.

Another influential early transhumanist was F. M. Esfandiary, who later changed his name to FM-2030. One of the first professors of future studies, FM taught at the New School for Social Research in New York in the 1960s and formed a school of optimistic futurists known as the UpWingers. In his book Are you a transhuman? (1989), he described what he saw as the signs of the emergence of the transhuman person, in his terminology indicating an evolutionary link towards posthumanity. (A terminological aside: an early use of the word transhuman was in the 1972-book of Ettinger, who doesnt now remember where he first encountered the term. The word transhumanism may have been coined by Julian Huxley in New Bottles for New Wine (1957); the sense in which he used it, however, was not quite the contemporary one.) Further, its use is evidenced in T.S. Elliots writing around the same time. And it is known that Dante Alighieri referred to the notion of the transhuman in historical writings.

In the 1970s and 1980s, several organizations sprung up for life extension, cryonics, space colonization, science fiction, media arts, and futurism. They were often isolated from one another, and while they shared similar views and values, they did not yet amount to any unified coherent worldview. One prominent voice from a standpoint with strong transhumanist elements during this era came from Marvin Minsky, an eminent artificial intelligence researcher.

In 1986, Eric Drexler published Engines of Creation, the first book-length exposition of molecular manufacturing. (The possibility of nanotechnology had been anticipated by Nobel Laureate physicist Richard Feynman in a now-famous after-dinner address in 1959 entitled There is Plenty of Room at the Bottom.) In this groundbreaking work, Drexler not only argued for the feasibility of assembler-based nanotechnology but also explored its consequences and began charting the strategic challenges posed by its development. Drexlers later writings supplied more technical analyses that confirmed his initial conclusions. To prepare the world for nanotechnology and work towards it safe implementation, he founded the Foresight Institute together with his then wife Christine Peterson in 1986.

Ed Regiss Great Mambo Chicken and the Transhuman Condition (1990) took a humorous look at transhumanisms hubristic scientists and philosophers. Another couple of influential books were roboticist Hans Moravecs seminal Mind Children (1988) about the future development of machine intelligence, and more recently Ray Kurzweils bestselling Age of Spiritual Machines (1999), which presented ideas similar to Moravecs. Frank Tiplers Physics of Immortality (1994), inspired by the writings of Pierre Teilhard de Chardin (a paleontologist and Jesuit theologian who saw an evolutionary telos in the development of an encompassing noosphere, a global consciousness) argued that advanced civilizations might come to have a shaping influence on the future evolution of the cosmos, although some were put off by Tiplers attempt to blend science with religion. Many science advocates, such as Carl Sagan, Richard Dawkins, Steven Pinker, and Douglas Hofstadter, have also helped pave the way for public understanding of transhumanist ideas.

In 1988, the first issue of the Extropy Magazine was published by Max More and Tom Morrow, and in 1992 they founded the Extropy Institute (the term extropy being coined as an informal opposite of entropy). The magazine and the institute served as catalysts, bringing together disparate groups of people with futuristic ideas. More wrote the first definition of transhumanism in its modern sense, and created his own distinctive brand of transhumanism, which emphasized individualism, dynamic optimism, and the market mechanism in addition to technology. The transhumanist arts genre became more self-aware through the works of the artist Natasha Vita-More. During this time, an intense exploration of ideas also took place on various Internet mailing lists. Influential early contributors included Anders Sandberg (then a neuroscience doctoral student) and Robin Hanson (an economist and polymath) among many others.

The World Transhumanist Association was founded in 1998 by Nick Bostrom and David Pearce to act as a coordinating international nonprofit organization for all transhumanist-related groups and interests, across the political spectrum. The WTA focused on supporting transhumanism as a serious academic discipline and on promoting public awareness of transhumanist thinking. The WTA began publishing the Journal of Evolution and Technology, the first scholarly peer-reviewed journal for transhumanist studies in 1999 (which is also the year when the first version of this FAQ was published). In 2001, the WTA adopted its current constitution and is now governed by an executive board that is democratically elected by its full membership. James Hughes especially (a former WTA Secretary) among others helped lift the WTA to its current more mature stage, and a strong team of volunteers has been building up the organization to what it is today.

Humanity+ developed after to rebrand transhumanism informing Humanity+ as a cooperative organization, seeking to pull together the leaders of transhumanism: from the early 1990s: Max More, Natasha Vita-More, Anders Sandberg; the late 1990s: Nick Bostrom, David Pearce, James Hughes; the 2000s: James Clement, Ben Goertzel, Giulio Prisco and many others. In short, it is based on the early work of Extropy Institute and WTA.

In the past couple of years, the transhumanist movement has been growing fast and furiously. Local groups are mushrooming in all parts of the world. Awareness of transhumanist ideas is spreading. Transhumanism is undergoing the transition from being the preoccupation of a fringe group of intellectual pioneers to becoming a mainstream approach to understanding the prospects for technological transformation of the human condition. That technological advances will help us overcome many of our current human limitations is no longer an insight confined to a few handfuls of techno-savvy visionaries. Yet understanding the consequences of these anticipated possibilities and the ethical choices we will face is a momentous challenge that humanity will be grappling with over the coming decades. The transhumanist tradition has produced a (still evolving) body of thinking to illuminate these complex issues that is unparalleled in its scope and depth of foresight.

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What is Transhumanism?

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Cryonics – Merkle

Read the Alcor Membership page and follow the instructions. Most members use life insurance to pay for their cryopreservation. Rudi Hoffman has written most of the life insurance policies in the cryonics community.

If you're interested, but not quite ready to sign up, become an Associate Member.

A common misconception is that cryonics freezes the dead. As the definition of "death" is "a permanent cessation of all vital functions" the future ability to revive a patient preserved with today's technology implies the patient wasn't dead. Cryonics is actually based on the more plausible idea that present medical practice has erred in declaring a patient "dead." A second opinion from a future physician one with access to a fundamentally better medical technology based on a mature nanotechnology lets us avoid the unpleasant risk that we might bury someone alive.

The major reason that cryonics is not more favorably viewed in the medical community is relatively easy to explain. Medicine relies on clinical trials. Put more simply, if someone proposes a technique for saving lives, the response is "Try it and see if it works." Methods that have not been verified by clinical trials are called "experimental," while methods that have been tried and failed are rejected.

In keeping with this tradition, we would like to conduct clinical trials of the effectiveness of cryopreservation to determine whether it does (or does not) work. The appropriate trials can be easily described. Cryonics proposes to cryopreserve people with today's technology in the expectation that medical technology of (say) the year 2115 will be able to cure them. Thus, the appropriate clinical trials would be to:

While this problem is not entirely unique to cryonics (the plight of a dying patient who wishes to know whether or not to take a new experimental treatment is well known), cryonics poses it in a qualitatively more severe fashion: we must wait longer to determine the outcome and we have no preliminary results to provide a clue about what that outcome might be. If a new treatment is being tested we normally have the results of animal trials and perhaps some preliminary results from human patients. Further, we expect to get reliable results within a small number of years. In the case of cryonics, we are quite literally awaiting the development of an entirely new medical technology. Preliminary results, even on experimental animals, are simply not available; and the final results won't be available for several decades.

Thus, while we can begin the clinical trials required to evaluate cryonics today, clinical trials cannot provide a timely answer about the effectiveness of cryonics. It is not possible (utilizing the paradigm of clinical trials) to draw conclusions today about whether physicians tomorrow will (or will not) be able to revive someone who was cryopreserved using today's technology.

The correct scientific answer to the question "Does cryonics work?" is: "The clinical trials are in progress. Come back in a century and we'll give you a reliable answer." The relevant question for those of us who don't expect to live that long is: "Would I rather be in the control group, or the experimental group?" We are forced by circumstances to answer that question without the benefit of knowing the results of the clinical trials.

When we think about this question, it is important to understand that future medical technology will be no mere incremental or evolutionary advance over today's medicine. Think of Hippocrates, the prehistoric Greek physician, watching a modern heart transplant. Advances in medical technology in future decades and centuries will be even more remarkable than the advances we have already seen in centuries past. At some point in the future almost any infirmity that could in principle be treated is likely to be treatable in practice as well. In principle, the coming ability to arrange and rearrange molecular and cellular structure in almost any way consistent with physical law will let us repair or replace almost any tissue in the human body. Whether it's a new liver, a more vital heart, a restored circulatory system, removing some cancerous cells, or some other treatment -- at some point, nanomedicine should let us revitalize the entire human body and even revive someone who was cryopreserved today.

How might we evaluate cryonics? Broadly speaking, there are two available courses of action: (1) sign up or (2) do nothing. And there are two possible outcomes: (1) it works or (2) it doesn't. This leads to the payoff matrix to the right. In using such a payoff matrix to evaluate the possible outcomes, we must decide what value the different outcomes have. What value do we place on a long and healthy life?

When evaluating the possible outcomes, it's important to understand that if you sign up and it works, that "Live" does not mean a long, wretched and miserable life. Many people fear they will wake up, but still suffer from the infirmities and morbidities that the elderly suffer from today. This is implausible for two very good reasons. First, the kinds of medical technologies that are required to restore today's cryonics patients will be able to restore and maintain good health for an indefinite period. The infirmities of old age will go the way of smallpox, black death, consumption, and the other scourges that once plagued humanity. Second, as long as we are unable to restore cryopreserved patients to satisfactory good physical and mental health, we'll keep them cryopreserved until we develop better medical technologies. To put these two points another way, when that future day arrives when we have a medical technology that can revive a patient who was dying of cancer today, and was cryopreserved with today's technology, that same medical technology should be able to cure their senile dementia and restore their musculature; they'll walk out into a future world healthy in mind and body. In the unlikely case it can't, we'll keep our patients in liquid nitrogen until we develop a medical technology that can.

It's also important to understand that technology is moving rapidly, and accelerating. When you wake up, your children and your younger friends and acquaintances are likely to be alive and well, along with most of your awakened friends from the cryonics community. While several decades might have passed, your social network within the cryonics community will still be there and likely many of the younger members of the rest of your social network.

While different people will answer these questions in different ways, this provides a useful framework in which to consider the problem.

At some point in the future we will have direct experimental proof that today's cryopreserved patients either can or cannot be revived by future medical technology. Unfortunately, most of us must decide today if we wish to pursue this option. If we wish to gain some insight today about the chance that cryonics will or will not work we must consider several factors, including most prominently (a) the kinds of damage that are likely to occur during cryopreservation and (b) the kinds of damage that future medical technologies might reasonably be able to repair. Those interested in pursuing this subject should read this web page which discusses the chances of success and The Molecular Repair of the Brain.

Recent coverage of cryonics is available from Google news.

There has been much discussion of cryonics in the blogosphere, notably including discussions at Overcoming Bias and Less Wrong. Ciphergoth has sought articles critical of cryonics.

California Magazine, Summer 2015, "Into the Deep Freeze: What Kind of Person Chooses to Get Cryonically Preserved?" "[Max] More [Alcor's President] comes across as a reasonable man who is acutely aware that most people think his ideas are insane, or repugnant, or both. Like most of the cryonicists I spoke to, he frames his points as appeals to logic, not emotion. His confidence is infectious."

Hopes & Fears, May 11, 2015, "I freeze people's brains for a living" "For me, cryopreservation was an obvious mechanical problem. Youve got molecules; why not lock them in place so that somebody can fix them later?" "I was an ENT physician, but I havent practiced for about five years now. I still have my license. My participation in the cryonics field happened very gradually."

ESPN, May 5, 2015, "The Greatest Hitter Who Ever Lived On" "In her book, Claudia writes what her father told the doctor. ... I'd like to have some more time with my two kids. "

Specter Defied, April 25, 2015, "How to sign up for Alcor cryo" "This article is intended for those who already think cryopreservation is a good idea but are putting it off since they don't know exactly what needs to be done."

The Dr. Oz Show, March 10, 2015, "Why Larry King Wants to Freeze His Body" "I think when you die, that's it. And I don't want it to be it. I want to be around. So I figure the only chance I have is to be frozen. And then, if they cure whatever I died of, I come back."

The List, March 12, 2015, "Live Forever by Freezing Your Body" "First and foremost I look forward to the future, I think it's going to be a great place. I want to live as long as possible." "Many pay for their cryonic treatment by naming the company itself, Alcor, as their life insurance beneficiary."

The Journal of Medical Ethics, February 25, 2015, "The case for cryonics" " insofar as the alternatives to cryonics are burial or cremation, and thus certain, irreversible death, even small chances for success can be sufficient to make opting for cryonics a rational choice."

The Onion, October 15, 2014, "Facebook Offers To Freeze Female EmployeesNewborn Children" "We recognize the many challenges women face starting a family and balancing a career, which is why our company will provide extensive support to female employees who want to preserve their infant in a frozen state of suspended animation until theyre ready for child-rearing, said Facebook spokesperson Mary Copperman, ..."

The Atlantic, August 26, 2014, "For $200,000, This Lab Will Swap Your Body's Blood for Antifreeze" "Cryopreservation is a darling of the futurist community. The general premise is simple: Medicine is continually getting better. Those who die today could be cured tomorrow. Cryonics is a way to bridge the gap between todays medicine and tomorrows."

The Huffington Post, June 23, 2014, "Should Cryonics, Cryothanasia, and Transhumanism Be Part of the Euthanasia Debate?" "Approximately 40 million people around the world have some form of dementia, according to a World Health Organization report. About 70 percent of those suffer from Alzheimer's. With average lifespans increasing due to rapidly improving longevity science, what are people with these maladies to do? Do those with severe cases want to be kept alive for years or even decades in a debilitated mental state just because modern medicine can do it?" "In the 21st Century--the age of transhumanism and brilliant scientific achievement--the question should be asked: Are there other ways to approach this sensitive issue?" "Recently, some transhumanists have advocated for cryothanasia, where a patient undergoes physician or self-administered euthanasia with the intent of being cryonically suspended during the death process or immediately afterward. This creates the optimum environment since all persons involved are on hand and ready to do their part so that an ideal freeze can occur."

Alcor, December 19, 2013, "Dr. Michio Kaku and Cryonics: Why Michio Kaku's Critique of Cryonics is Bogus" "You'd expect that a man of that learning, and knowledge, and experience ... would have done his research and get things right. Unfortunately, just about every single point in that video was incorrect."

BBC, October 31, 2013, "Will we ever bring the dead back to life?" "The woods cool temperature, it turned out, had prevented the womans cells from breaking down as quickly as they would have in a warmer environment, allowing her to lay dead in the forest for around four hours, plus survive an additional six hours between the time the passerby called the ambulance and the time her heart began beating again. Three weeks later, she left the hospital, and today she is happily married and recently delivered a baby."

The Guardian, September 20, 2013, "Cryonics: the people hoping to give death a cold shoulder" "Scores of Brits have also signed up for what the movement has dubbed "a second chance at life""

Singularity Weblog, September 12, 2013, "My Video Tour of Alcor and Interview with CEO Max More" "During our visit CEO Dr. More walked us through the Alcor facilities as well as the process starting after clinical death is proclaimed, through the cooling of the body and its vitrification, and ending in long term storage."

Science Omega, July 1, 2013, "Exploring cryonics: Could science offer new life after death?" "Medical advances have made it possible given favourable circumstances for physicians to bring patients, who are clinically dead, back to life." ... " cryonics has been viewed as somewhat of a fringe science since its inception. However, advances within fields such as regenerative medicine and nanomedicine have caused some experts to acknowledge the fields growing potential. Last month, for example, three academics from the University of Oxford revealed that, once dead, they will be cryogenically preserved until it becomes possible to bring them back to life."

The Independent, June 9, 2013: "Academics at Oxford University pay to be cryogenically preserved and brought back to life in the future"

"Nick Bostrom, professor of philosophy at the Future of Humanity Institute [FHI] and his co researcher Anders Sandberg have agreed to pay an American company to detach and deep freeze their heads in the advent of their deaths.

Colleague Stuart Armstrong is instead opting to have his whole body frozen. Preserving the full body is technically more difficult to achieve and can cost up to 130,000.

Bostrom, Armstrong, Sandberg are lead researchers at the FHI, a part of the prestigious Oxford Martin School where academics complete research into problems affecting the globe, such as a climate change."

"It costs me 25 a month in premiums to cover the cost of getting cryo-preserved, and that seems a good bet, he [Armstrong] said. Its a lot cheaper than joining a gym, which is most peoples way of trying to prolong life."

BuzzFeed, June 6, 2013, "The Immortality Business" "The richest vein of professed cryonicists is, not surprisingly, in the world of technology." Alcors "public-facing members include prolific inventor and Singularity cleric Ray Kurzweil; nanotechnology pioneer Ralph Merkle; and Marvin Minsky, co-founder of MITs artificial intelligence laboratory."

The Observer, April 6th, 2013: "Sam Parnia the man who could bring you back from the dead" '"The longest I know of is a Japanese girl I mention in the book," Parnia says. "She had been dead for more than three hours. ... Afterwards, she returned to life perfectly fine and has, I have been told, recently had a baby."' "One of the stranger things you realise in reading Parnia's book is the idea that we might be in thrall to historical perceptions of life and death and that these ultimate constants have lately become vaguer than most of us would allow."

Discovery Channel, April 16th, 2013: "Maria Entraigues Discovery Channel interview" In Spanish. "Alcor is the place where I will take a little nap so that I can wake up in the future..."

Cryonics, January 2013: "Alcor-40 Conference Review" "From the science of cryopreservation to the implications of neural network research on cryonics to strategies for preserving your assets as well as yourself, no stone was left unturned and no question unasked."

Phoenix New Times, September 17th, 2012: "Best Second Chance - 2012: ALCOR Life Extension Foundation" "ALCOR ... specializes in cryonics, the science of preserving bodies at sub-zero temperatures for eventual reanimation, possibly centuries from now."

CNBC, September 20th, 2012: "William Maris: Google Ventures Managing Partner" "What's the most exciting areas right now?" ... "There are two areas. One, I'm interested in macro trends that are 5 or 10 years out, things like radical life extension, cryogenics, nanotechnology, and then there are trends that are occuring sooner." ... "So go back to cryogenics, how realistic is that idea at this point?"... " we're looking for entrepreneurs that have a healthy disregard for the impossible. If I start from a place by saying that's not realistic, or not possible, we won't make any investments. So I think it's very realistic." ... "I want to know if this is a reality that we could see sometime in my lifetime?" "It's a reality now, there are companies that specialize in cryogenics."

OraTVnetwork, July 17th, 2012: "Seth MacFarlane & Larry King on Cryonics" (41 seconds) Larry King: "How about we get frozen together?" Seth MacFarlane: "Let's do it!"

PBS Newshour, July 10th, 2012: "As Humans and Computers Merge ... Immortality?" Ray Kurzweil, co-founder, Singularity University: "People say, oh, I don't want to live past 100. And I say, OK, I would like to hear you say that when you're 100."

Newsmax Health, December 7th, 2011: "Larry King's Vow to Freeze His Dead Body Is Not Crazy, Experts Say" "the 78-year-old King stated, I wanna be frozen, on the hope that theyll find whatever I died of and theyll bring me back."

SENS5 Conference, September 3rd, 2011: "Cryonic Life Extension" "Cryonics enables the transport of critically ill people through time in an unchanging state to a time when more advanced medical and repair technologies are available" said Max More, President and CEO of Alcor Life Extension Foundation.

Science Channel's Through the Wormhole (Season 2), July 15th 2011: "Cryogenic Preservation" "Cryogenic freezing is a process that could successfully preserve a human body over an extended period of time."

Time, February 10th 2011: "2045: The Year Man Becomes Immortal" "Old age is an illness like any other, and what do you do with illnesses? You cure them."

Rolling Stone, December 2010: "Life on the Rocks: can you bring people back from the dead?" (slow site) "Isn't it a leap of faith to believe in something that hasn't happened yet? 'The comparison's more like talking to someone 150 years ago and saying, "In a little while, humans are going to have flying machines."'"

Lightspeed, October 2010: "Considering Cryonics" Author and Physics Professor Gregory Benford looks at cryonics, and says "...its a rational gamble, especially when you consider that cryonicists buy life insurance policies which pay their organization upon their death..."

Singularity Summit 2010, August 15th, 2010: "Modifying the Boundary between Life and Death" Lance Becker, MD, Director, Center for Resuscitation Science, Emergency Medicine, University of Pennsylvania: "Our initial results are very encouraging. We have taken 6 dead people ... plugged those patients into cardiopulmonary bypass and we have a 50% survival rate out of those 6 patients". On cryonics: "I look forward to seeing that field [cryonics] be synergistic with some of what we're doing."

New York Times, July 5th, 2010: "Until Cryonics Do Us Part" Cryonics can produce hostility from spouses who are not cryonicists.

Colorado Court Order, March 1, 2010: "IN THE MATTER OF THE ESTATE OF: MARY ROBBINS" "The Court finds that the evidence clearly shows Mary's decision in 2006 for Alcor to preserve her last remains by cryonic suspension was an informed and resolute one." "Alcor shall have custody of Mary's last remains..."

Organogenesis, Vol 5 Issue 3, 2009: "Physical and biological aspects of renal vitrification" "We report here the detailed case history of a rabbit kidney that survived vitrification and subsequent transplantation"

The Institution of Engineering and Technology, November 5, 2008: "A Science Without a Deadline" "If sceptics dont want to pursue this area, thats fine, but I ask them not to interfere with my own efforts to save the lives of myself and the people I love"

BBC News,October 20, 2008: "Doctors get death diagnosis tips" "...there is enough ambiguity in diagnosing death that doctors need guidance" "...like low body temperature when it is inappropriate to confirm death." (audio)

Cryonics, 4th Quarter 2008: "A Cryopreservation Revival Scenario using MNT" Molecular nanotechnology is the most compelling approach ever put forward for comprehensive repair of cryopreservation injury with maximum retention of original biological information.

Newsweek, July 23, 2007: "Back From the Dead" "The other is to scan the entire three-dimensional molecular array of the brain into a computer which could hypothetically reconstitute the mind, either as a physical entity or a disembodied intelligence in cyberspace."

Newsweek, May 7, 2007: "To Treat the Dead" ""After one hour," he says, "we couldn't see evidence the cells had died. We thought we'd done something wrong." In fact, cells cut off from their blood supply died only hours later."

Channel 5 (UK), 2006 : "Cryonics Freeze Me" (A.K.A. "Death in the Deep Freeze") "Almost every major advance has met with its critics, who have said that it's impossible, unworkable, uneconomical; and then, of course, when it's demonstrated, they announce that it's obvious and they knew it all along." (If you have a link to the video, please email it to me).

The Wall Street Journal, January 21st 2006: "A Cold Calculus Leads Cryonauts To Put Assets on Ice" "At least a dozen wealthy American and foreign businessmen are testing unfamiliar legal territory by creating so-called personal revival trusts designed to allow them to reclaim their riches hundreds, or even thousands, of years into the future."

This Is London, May 25th 2004: "Sperm 'can be kept for thousands of years'" "...sperm could survive 5,000 or 6,000 years stored in liquid nitrogen."

The Arizona State Legislature is not regulating cryonics.

Reasononline, February 25th 2004: "Regulating the Biggest Chill" "Arizona's state legislature is about to consider one of the silliest pieces of "consumer protection" legislation ever devised."

Guardian Unlimited, January 23rd 2004, "House of the temporarily dead" "Officially, the building is "the world's first comprehensive facility devoted to life extension research and cryopreservation", a six-acre structure that will house research laboratories, animal and plant DNA, and up to 10,000 temporarily dead people."

Science News, December 21st 2002: "Cold Comfort: A futuristic play of cryogenic proportions" an amusing story in which Ted Williams, Carl Sagan and Richard Feynman awake in 2102 and find they are wards of the Martha Stewart Living Foundation. Says Ted: "...the Red Sox should have won a World Series by now."

The Fifth Alcor Conference on Extreme Life Extension resulted in several articles:

Wired News, November 18th 2002: "Ray Kurzweil's Plan: Never Die" "Ray Kurzweil, celebrated author, inventor and geek hero, plans to live forever."

Wired News, November 20th 2002: A Few Ways to Win Mortality War "Discussions among leading researchers in nanotechnology, cloning and artificial intelligence focused on much more than cryonics, the process of freezing the body in liquid nitrogen after death to be later reanimated. Cryonics is basically a backup plan if technology doesn't obliterate mortality first."

Wired News, November 20th 2002: Who Wants to Live Forever? "Gregory Benford, of the University of California at Irvine, believes the public should know that 'cryonicists aren't crazy, they're just really great, sexy optimists.'"

KurzweilAI.net, November 22nd 2002: The Alcor Conference on Extreme Life Extension "Bringing together longevity experts, biotechnology pioneers, and futurists, the conference explored how the emerging technologies of biotechnology, nanotechnology, and cryonics will enable humans to halt and ultimately reverse aging and disease and live indefinitely."

Coverage of cryonics related to the Ted Williams case was voluminous. Wikipedia describes the events succinctly. Here are links to a few contemporaneous articles:

Sports Illustrated, August 2nd 2003: "Splendid Splinter chilling in Scottsdale" Sports Illustrated, June 30th 2003: "Chillin' with the Splinter" The New York Times, September 26th 2002: "Fight Over Williams May End" CNN Sports Illustrated, August 13th 2002: "Williams' eldest daughter asks judge to keep jurisdiction" USA Today, July 28th 2002: "Vitrification could keep tissue safe during the big chill" The New York Times, July 16th 2002: "They've Seen the Future and Intend to Live It" The New York Times, July 9th 2002: "Even for the Last .400 Hitter, Cryonics Is the Longest Shot" (Note that the Boston Globe links and others that have gone dead have been deleted).

Christopher Hitchens quote, February 15, 2011: "If someone is reported dead on Tuesday, and you see them on Friday, the overwhelming, the obvious conclusion is that the initial report was mistaken."

Howard Lovy's blog August 27th 2003: "Unfrozen Cave Men"

Reason Online, August 2002: "Forever Young: The new scientific search for immortality"

New Scientist, September 2nd 2002: "New Scientist offers prize to die for." "When the winner of the New Scientist promotion is pronounced legally dead, he or she will be ... suspended in liquid nitrogen at 196, in a state known as cryonic preservation[sic]."

KRON 4 News, Nightbeat, May 3rd 2001: "Frozen for Life" [medical] advances are giving new credibility to cryonics.

Wired News, July 20th 2001: "Cryonics Over Dead Geeks' Bodies"

Scientific American, September 2001: "Nano nonsense and cryonics"

Search PubMed for published articles on cryonics.

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Cryonics - Merkle

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Stem Cell Therapy for Neuromuscular Diseases | InTechOpen

1. Introduction

Neuromuscular disease is a very broad term that encompasses many diseases and aliments that either directly, via intrinsic muscle pathology, or indirectly, via nerve pathology, impair the functioning of the muscles. Neuromuscular diseases affect the muscles and/or their nervous control and lead to problems with movement. Many are genetic; sometimes, an immune system disorder can cause them. As they have no cure, the aim of clinical treatment is to improve symptoms, increase mobility and lengthen life. Some of them affect the anterior horn cell, and are classified as acquired (e.g. poliomyelitis) and hereditary (e.g. spinal muscular atrophy) diseases. SMA is a genetic disease that attacks nerve cells, called motor neurons, in the spinal cord. As a consequence of the lost of the neurons, muscles weakness becomes to be evident, affecting walking, crawling, breathing, swallowing and head and neck control. Neuropathies affect the peripheral nerve and are divided into demyelinating (e.g. leucodystrophies) and axonal (e.g. porphyria) diseases. Charcot-Marie-Tooth (CMT) is the most frequent hereditary form among the neuropathies and its characterized by a wide range of symptoms so that CMT-1a is classified as demyelinating and CMT-2 as axonal (Marchesi & Pareyson, 2010). Defects in neuromuscular junctions cause infantile and non-infantile Botulism and Myasthenia Gravis (MG). MG is a antibody-mediated autoimmune disorder of the neuromuscular junction (NMJ) (Drachman, 1994; Meriggioli & Sanders, 2009). In most cases, it is caused by pathogenic autoantibodies directed towards the skeletal muscle acetylcholine receptor (AChR) (Patrick & Lindstrom, 1973) while in others, non-AChR components of the postsynaptic muscle endplate, such as the muscle-specific receptor tyrosine kinase (MUSK), might serve as targets for the autoimmune attack (Hoch et al., 2001). Although the precise origin of the autoimmune response in MG is not known, genetic predisposition and abnormalities of the thymus gland such as hyperplasia and neoplasia could have an important role in the onset of the disease (Berrih et al., 1984; Roxanis et al., 2001).

Several diseases affect muscles: they are classified as acquired (e.g. dermatomyositis and polymyositis) and hereditary (e.g. myotonic disorders and myopaties) forms. Among the myopaties, muscular dystrophies are characterized by the primary wasting of skeletal muscle, caused by mutations in the proteins that form the link between the cytoskeleton and the basal lamina (Cossu & Sampaolesi, 2007). Mutations in the dystrophin gene cause severe form of hereditary muscular diseases; the most common are Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD). DMD patients suffer for complete lack of dystrophin that causes progressive degeneration, muscle wasting and death into the second/third decade of life. Beside, BMD patients show a very mild phenotype, often asymptomatic primarily due to the expression of shorter dystrophin mRNA transcripts that maintain the coding reading frame. DMD patients muscles show absence of dystrophin and presence of endomysial fibrosis, small fibers rounded and muscle fiber degeneration/regeneration. Untreated, boys with DMD become progressively weak during their childhood and stop ambulation at a mean age of 9 years, later with corticosteroid treatment (12/13 yrs). Proximal weakness affects symmetrically the lower (such as quadriceps and gluteus) before the upper extremities, with progression to the point of wheelchair dependence. Eventually distal lower and then upper limb weakness occurs. Weakness of neck flexors is often present at the beginning, and most patients with DMD have never been able to jump. Wrist and hand muscles are involved later, allowing the patients to keep their autonomy in transfers using a joystick to guide their wheelchair. Musculoskeletal contractures (ankle, knees and hips) and learning difficulties can complicate the clinical expression of the disease. Besides this weakness distribution in the same patient, a deep variability among patients does exist. They could express a mild phenotype, between Becker and Duchenne dystrophy, or a really severe form, with the loss of deambulation at 7-8 years. Confinement to a wheelchair is followed by the development of scoliosis, respiratory failure and cardiomyopathy. In 90% of people death is directly related to chronic respiratory insufficiency (Rideau et al., 1983). The identification and characterization of dystrophin gene led to the development of potential treatments for this disorder (Bertoni, 2008). Even if only corticosteroids were proven to be effective on DMD patient (Hyser and Mendell, 1988), different therapeutic approaches were attempted, as described in detail below (see section 7).

The identification and characterization of the genes whose mutations caused the most common neuromuscular diseases led to the development of potential treatments for those disorders. Gene therapy for neuromuscular disorders embraced several concepts, including replacing and repairing a defective gene or modifying or enhancing cellular performance, using gene that is not directly related to the underlying defect (Shavlakadze et al., 2004). As an example, the finding that DMD pathology was caused by mutations in the dystrophin gene allowed the rising of different therapeutic approaches including growth-modulating agents that increase muscle regeneration and delay muscle fibrosis (Tinsley et al., 1998), powerful antisense oligonucleotides with exon-skipping capacity (Mc Clorey et al., 2006), anti-inflammatory or second-messenger signal-modulating agents that affect immune responses (Biggar et al., 2006), agents designed to suppress stop codon mutations (Hamed, 2006). Viral and non-viral vectors were used to deliver the full-length - or restricted versions - of the dystrophin gene into stem cells; alternatively, specific antisense oligonucleotides were designed to mask the putative splicing sites of exons in the mutated region of the primary RNA transcript whose removal would re-establish a correct reading frame. In parallel, the biology of stem cells and their role in regeneration were the subject of intensive and extensive research in many laboratories around the world because of the promise of stem cells as therapeutic agents to regenerate tissues damaged by disease or injury (Fuchs and Segre, 2000; Weissman, 2000). This research constituted a significant part of the rapidly developing field of regenerative biology and medicine, and the combination of gene and cell therapy arose as one of the most suitable possibility to treat degenerative disorders. Several works were published in which stem cell were genetically modified by ex vivo introduction of corrective genes and then transplanted in donor dystrophic animal models.

Stem cells received much attention because of their potential use in cell-based therapies for human disease such as leukaemia (Owonikoko et al., 2007), Parkinsons disease (Singh et al., 2007), and neuromuscular disorders (Endo, 2007; Nowak and Davies, 2004). The main advantage of stem cells rather than the other cells of the body is that they can replenish their numbers for long periods through cell division and, they can produce a progeny that can differentiate into multiple cell lineages with specific functions (Bertoni, 2008). The candidate stem cell had to be easy to extract, maintaining the capacity of myogenic conversion when transplanted into the host muscle and also the survival and the subsequent migration from the site of injection to the compromise muscles of the body (Price et al., 2007). With the advent of more sensitive markers, stem cell populations suitable for clinical experiments were found to derive from multiple region of the body at various stage of development. Numerous studies showed that the regenerative capacity of stem cells resided in the environmental microniche and its regulation. This way, it could be important to better elucidate the molecular composition cytokines, growth factors, cell adhesion molecules and extracellular matrix molecules - and interactions of the different microniches that regulate stem cell development (Stocum, 2001).

Several groups published different works concerning adult stem cells such as muscle-derived stem cells (Qu-Petersen et al., 2002), mesoangioblasts (Cossu and Bianco, 2003), blood- (Gavina et al., 2006) and muscle (Benchaouir et al., 2007)-derived CD133+ stem cells. Although some of them are able to migrate through the vasculature (Benchaouir et al., 2007; Galvez et al., 2006; Gavina et al., 2006) and efforts were done to increase their migratory ability (Lafreniere et al., 2006; Torrente et al., 2003a), poor results were obtained.

Embryonic and adult stem cells differ significantly in regard to their differentiation potential and in vitro expansion capability. While adult stem cells constitute a reservoir for tissue regeneration throughout the adult life, they are tissue-specific and possess limited capacity to be expanded ex vivo. Embryonic Stem (ES) cells are derived from the inner cell mass of blastocyst embryos and, by definition, are capable of unlimited in vitro self-renewal and have the ability to differentiate into any cell type of the body (Darabi et al., 2008b). ES cells, together with recently identified iPS cells, are now broadly and extensively studied for their applications in clinical studies.

Embryonic stem cells are pluripotent cells derived from the early embryo that are characterized by the ability to proliferate over prolonged periods of culture remaining undifferentiated and maintaining a stable karyotype (Amit and Itskovitz-Eldor, 2002; Carpenter et al., 2003; Hoffman and Carpenter, 2005). They are capable of differentiating into cells present in all 3 embryonic germ layers, namely ectoderm, mesoderm, and endoderm, and are characterized by self-renewal, immortality, and pluripotency (Strulovici et al., 2007).

hESCs are derived by microsurgical removal of cells from the inner cell mass of a blastocyst stage embryo (Fig. 1). The ES cells can be also obtained from single blastomeres. This technique creates ES cells from a single blastomere directly removed from the embryo bypassing the ethical issue of embryo destruction (Klimanskaya et al., 2006). Although maintaining the viability of the embryo, it has to be determined whether embryonic stem cell lines derived from a single blastomere that does not compromise the embryo can be considered for clinical studies. Cell Nuclear Transfer (SCNT): Nuclear transfer, also referred to as nuclear cloning, denotes the introduction of a nucleus from an adult donor cell into an enucleated oocyte to generate a cloned embryo (Wilmut et al., 2002).

ESCs differentiation. Differentiation potentiality of human embryonic stem cell lines. Human embryonic stem cell pluripotency is evaluated by the ability of the cells to differentiate into different cell types.

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Stem Cell Therapy for Neuromuscular Diseases | InTechOpen

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